Piezo Ion Channels in Cardiovascular Mechanobiology
نویسندگان
چکیده
منابع مشابه
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module of Piezo1 that resembles the pore arc...
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Mechanosensory transduction underlies touch, hearing and proprioception and requires mechanosensitive channels that are directly gated by forces; however, the molecular identities of these channels remain largely elusive. A new study has identified Piezo1 and Piezo2 as a novel class of mechanosensitive channels.
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ژورنال
عنوان ژورنال: Trends in Pharmacological Sciences
سال: 2019
ISSN: 0165-6147
DOI: 10.1016/j.tips.2019.10.002